Molecular and Biochemical Parameters Related to Plasma Mannose Levels in Coronary Artery Disease Among Nondiabetic Patients

Genet Test Mol Biomarkers. 2020 Sep;24(9):562-568. doi: 10.1089/gtmb.2020.0095. Epub 2020 Aug 6.


Aims: Nondiabetic patients were studied to determine whether modest elevations in plasma mannose may be associated with a greater incidence of coronary artery disease (CAD). Materials and Methods: Plasma insulin, mannose, glucose, hexokinase 1-2, GLUT1-GLUT4 levels, and serum mannose phosphate isomerase enzyme levels were evaluated with respect to subsequent CAD using records from 120 nondiabetic CAD patients and 120 healthy volunteers. CAD was identified from myocardial infarction and new diagnoses of angina. Results: Of 120 nondiabetic CAD patients studied, their plasma GLUT4 and HK1 levels were significantly lower than those of the control group. In addition, a significant increase in plasma mannose levels was found in the patient group compared to the control group. Conclusion: Our findings showed that elevated baseline mannose levels in plasma are associated with an increased risk of CAD over time.

Keywords: coronary vascular disease (CAD); insulin; nondiabetic; plasma mannose level.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Blood Glucose / analysis
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / genetics
  • Coronary Artery Disease / metabolism*
  • Female
  • Glucose Transporter Type 1 / genetics
  • Glucose Transporter Type 4 / genetics
  • Hexokinase / genetics
  • Humans
  • Male
  • Mannose / analysis*
  • Mannose / blood
  • Mannose / genetics
  • Middle Aged
  • Myocardial Infarction / metabolism
  • Plasma / chemistry
  • Risk Factors
  • Turkey


  • Biomarkers
  • Blood Glucose
  • Glucose Transporter Type 1
  • Glucose Transporter Type 4
  • SLC2A1 protein, human
  • SLC2A4 protein, human
  • HK1 protein, human
  • HK2 protein, human
  • Hexokinase
  • Mannose