Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

doi:10.14336/AD.2019.0820

Review

. 2020 Jul 23;11(4):927-945.

doi: 10.14336/AD.2019.0820. eCollection 2020 Jul.

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Lijun Zhao¹, Jianzhong Cao², Kexin Hu¹, Xiaodong He², Dou Yun¹, Tanjun Tong¹, Limin Han¹

Affiliations

¹ 1Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Beijing, China.
² 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

PMID: 32765955
PMCID: PMC7390530
DOI: 10.14336/AD.2019.0820

Review

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Lijun Zhao et al. Aging Dis. 2020.

. 2020 Jul 23;11(4):927-945.

doi: 10.14336/AD.2019.0820. eCollection 2020 Jul.

Authors

Lijun Zhao¹, Jianzhong Cao², Kexin Hu¹, Xiaodong He², Dou Yun¹, Tanjun Tong¹, Limin Han¹

Affiliations

¹ 1Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Beijing, China.
² 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

PMID: 32765955
PMCID: PMC7390530
DOI: 10.14336/AD.2019.0820

Abstract

Sirtuins, initially described as histone deacetylases and gene silencers in yeast, are now known to have many more functions and to be much more abundant in living organisms. The increasing evidence of sirtuins in the field of ageing and age-related diseases indicates that they may provide novel targets for treating diseases associated with aging and perhaps extend human lifespan. Here, we summarize some of the recent discoveries in sirtuin biology that clearly implicate the functions of sirtuins in the regulation of aging and age-related diseases. Furthermore, human sirtuins are considered promising therapeutic targets for anti-aging and ageing-related diseases and have attracted interest in scientific communities to develop small molecule activators or drugs to ameliorate a wide range of ageing disorders. In this review, we also summarize the discovery and development status of sirtuin-targeted drug and further discuss the potential medical strategies of sirtuins in delaying aging and treating age-related diseases.

Keywords: age-related diseases; aging; cancer; sirtuins.

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Conflict of interest statement

Competing interests The authors declare that they have no competing interests.

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References

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[1] Klar AJ, Fogel S, Macleod K (1979). MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE. Genetics, 93:37-50. - PMC - PubMed

[2] Klar AJ, Fogel S, Macleod K (1979). MAR1-a Regulator of the HMa and HMalpha Loci in SACCHAROMYCES CEREVISIAE. Genetics, 93:37-50. - PMC - PubMed

[3] Michan S, Sinclair D (2007). Sirtuins in mammals: insights into their biological function. Biochem J, 404:1-13. - PMC - PubMed

[4] Michan S, Sinclair D (2007). Sirtuins in mammals: insights into their biological function. Biochem J, 404:1-13. - PMC - PubMed

[5] Kaeberlein M, McVey M, Guarente L (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev, 13:2570-2580. - PMC - PubMed

[6] Kaeberlein M, McVey M, Guarente L (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev, 13:2570-2580. - PMC - PubMed

[7] Vaquero A (2009). The conserved role of sirtuins in chromatin regulation. Int J Dev Biol, 53:303-322. - PubMed

[8] Vaquero A (2009). The conserved role of sirtuins in chromatin regulation. Int J Dev Biol, 53:303-322. - PubMed

[9] Frye RA (2000). Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun, 273:793-798. - PubMed

[10] Frye RA (2000). Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun, 273:793-798. - PubMed

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Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

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Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

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