In vitro effects of low intensity direct current generated silver on eukaryotic cells

J Oral Maxillofac Surg. 1988 Feb;46(2):128-33. doi: 10.1016/0278-2391(88)90264-9.


An examination of the effects of low intensity direct current generated silver, (LIDC Ag) on several types of eukaryotic microorganisms and cell culture lines suggests that LIDC Ag has an appropriate selective toxicity for prokaryotic cells. It appears that levels of this agent could be obtained clinically that would have marked bacteriostatic activity and yet have little or no effect on mammalian cells.

MeSH terms

  • Animals
  • Bacteria / drug effects
  • Cell Division / drug effects
  • Cell Line
  • Cells / drug effects*
  • Electrolysis*
  • Eukaryotic Cells / drug effects*
  • Fibroblasts / drug effects
  • HeLa Cells / drug effects
  • Humans
  • Lymphocytes / drug effects
  • Mice
  • Saccharomyces cerevisiae / drug effects
  • Silver / pharmacology*
  • Silver / toxicity
  • Tetrahymena / drug effects


  • Silver