New drug therapy for peripheral vascular disease includes the use of nifedipine or sympathetic blocking agents for Raynaud's phenomenon and the use of lower doses of warfarin to prevent recurrence of thromboembolic disease. In prophylaxis of deep venous thrombosis, minidose heparin with or without dihydroergotamine and pneumatic boots are effective. Exercise regimens and the cessation of smoking remain the best therapy for intermittent claudication.