Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

Nat Commun. 2020 Aug 7;11(1):3983. doi: 10.1038/s41467-020-17787-0.

Abstract

Frontal top-down cortical neurons projecting to sensory cortical regions are well-positioned to integrate long-range inputs with local circuitry in frontal cortex to implement top-down attentional control of sensory regions. How adolescence contributes to the maturation of top-down neurons and associated local/long-range input balance, and the establishment of attentional control is poorly understood. Here we combine projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood. Chemogenetic suppression of top-down neuron activity selectively during adolescence, but not later periods, produces long-lasting visual attentional behavior deficits, and results in excessive loss of local excitatory inputs in adulthood. Our study reveals an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Aging / physiology*
  • Animals
  • Attention / physiology*
  • Behavior, Animal / physiology*
  • Channelrhodopsins / metabolism
  • Gyrus Cinguli / physiology
  • Male
  • Mice, Inbred C57BL
  • Models, Neurological
  • Neural Inhibition / physiology
  • Neurons / physiology*
  • Presynaptic Terminals / physiology
  • Rabies / physiopathology
  • Synapses / physiology
  • Vision, Ocular / physiology

Substances

  • Channelrhodopsins