α7 nicotinic receptors contributes to glutamatergic activity in the hippocampus of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)

J Neural Transm (Vienna). 2020 Oct;127(10):1441-1446. doi: 10.1007/s00702-020-02239-2. Epub 2020 Aug 8.

Abstract

Hyperglutamatergic activity in the hippocampus is a major feature of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Here we investigated whether tonic α7 nicotinic receptor (nAChR) activity could contribute to enhanced glutamatergic activity in the hippocampus of patients with MTLE-HS. Results showed that frequency and amplitude of glutamatergic events recorded from pyramidal neurons in the hippocampal samples obtained from patients with MTLE-HS were altered by α7 nAChR antagonist, methyllycaconitine, suggesting α7 nAChRs may influence hyperexcitability in MTLE-HS.

Keywords: Drug-resistant epilepsy; Glutamate receptors; Mesial temporal lobe epilepsy; Patch-clamp technique; α7 nicotinic receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epilepsy, Temporal Lobe* / pathology
  • Hippocampus / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Sclerosis / pathology
  • Synaptic Transmission
  • alpha7 Nicotinic Acetylcholine Receptor / metabolism*

Substances

  • Chrna7 protein, human
  • alpha7 Nicotinic Acetylcholine Receptor