Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces

Shinya Fukizawa; Mai Yamashita; Shiho Fujisaka; Kazuyuki Tobe; Yuji Nonaka; Norihito Murayama

doi:10.12938/bmfh.2019-045

Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces

Biosci Microbiota Food Health. 2020;39(3):100-108. doi: 10.12938/bmfh.2019-045. Epub 2020 Feb 21.

Authors

Shinya Fukizawa¹, Mai Yamashita¹, Shiho Fujisaka², Kazuyuki Tobe², Yuji Nonaka¹, Norihito Murayama¹

Affiliations

¹ Research Institute, Suntory Global Innovation Center Limited, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
² First Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194, Japan.

Abstract

The aim of this study was to verify the effect of treatment with isoxanthohumol (IX) on the metabolomics profile of mouse feces to explore the host-intestinal bacterial interactions at the molecular level. The fecal contents of several amino acids in the high-fat diet (HFD) + 0.1% IX group (treated with IX mixed in diets for 12 weeks) were significantly lower than in the HFD group. The fecal contents of the secondary bile acid deoxycholic acid (DCA) in the HFD + 180 mg/kg IX group (orally treated with IX for 8 weeks) were significantly lower than in the HFD group; the values in the HFD group were higher than those in the normal diet (ND) group. Administration of IX changed the fecal metabolomics profile. For some metabolites, IX normalized HFD-induced fluctuations.

Keywords: amino acids; bile acids; feces; isoxanthohumol; metabolomics.