Response to tyrosine kinase inhibitors in lung adenocarcinoma with the rare epidermal growth factor receptor mutation S768I and G724S: A case report and literature review

Thorac Cancer. 2020 Sep;11(9):2743-2748. doi: 10.1111/1759-7714.13606. Epub 2020 Aug 9.


Mutations in the epidermal growth factor receptor (EGFR) are drivers of a subset of lung cancers. In recent years, the treatment of non-small cell lung cancer (NSCLC), especially with EGFR inhibitors, has made rapid progress, and the median progression-free survival (PFS) of patients with EGFR gene-sensitive mutations has been significantly prolonged. However, the response effect of some uncommon EGFR mutations to tyrosine kinase inhibitors (TKIs) remains unclear. Here, we present a patient with multiple EGFR mutations that highlights tumor heterogeneity leading to a mixed molecular response to targeted drugs and emphasizes the complexity of EGFR-driven lung cancer. He received chemotherapy and molecular-targeted treatment including icotinib, afatinib, osimertinib and afatinib + osimertinib. In conclusion, patients with lung adenocarcinoma harboring the EGFR S768I and G724S mutations appear less sensitive to icotinib than patients with sensitive EGFR. However, the patient in our report benefited from treatment with afatinib. Here, we hope to provide information for the treatment of rare and compound mutations in patients.

Keywords: EGFR G724S; EGFR S768I; epidermal growth factor receptor (EGFR); rare mutation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma of Lung / genetics*
  • Adenocarcinoma of Lung / pathology
  • Aged
  • ErbB Receptors / metabolism*
  • Female
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • Male
  • Mutation
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use*


  • Protein Kinase Inhibitors
  • ErbB Receptors