Pickles and warfarin interaction: a case-based review

Clin Rheumatol. 2021 Apr;40(4):1621-1624. doi: 10.1007/s10067-020-05324-9. Epub 2020 Aug 10.

Abstract

A 36-year-old woman with a history of lupus and antiphospholipid syndrome controlled by warfarin presented to the hospital with left periorbital ecchymosis. She was found to have an INR of 9 despite maintaining her normal warfarin dose of 12.5 mg/15 mg alternating qd. The only identifiable precipitating factor was that the patient recently stopped eating dill pickles. Limiting dietary vitamin K while on warfarin therapy was once considered best practice. However, studies have demonstrated that maintaining a consistent intake of vitamin K is more important than the quantity. Still, many patients on warfarin remain unaware of which foods contain large amounts of vitamin K and are, therefore, susceptible to bleeding sequelae. Practitioners should be educated to inform patients to consume a steady amount of vitamin K in their diet, identify which foods contain vitamin K, and include pickles on that list.

Keywords: Antiphospholipid; Pickles; Vitamin K; Warfarin.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anticoagulants / adverse effects
  • Diet
  • Female
  • Fermented Foods*
  • Humans
  • International Normalized Ratio
  • Vitamin K
  • Warfarin* / adverse effects

Substances

  • Anticoagulants
  • Vitamin K
  • Warfarin