Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

Nanoscale. 2020 Aug 20;12(32):16705-16709. doi: 10.1039/d0nr03435e.


Methylstilbene-alt-maleic acid copolymers spontaneously convert biological membranes into bilayer discs with ∼20 nm diameters. This readily functionalizable class of copolymers has the compositional homogeneity, hydrophobicity, dynamics, and charge that may help to achieve optimal structural resolution, membrane dissolution, stability, and broad utility.