Electrochemical determination of chloramphenicol and metronidazole by using a glassy carbon electrode modified with iron, nitrogen co-doped nanoporous carbon derived from a metal-organic framework (type Fe/ZIF-8)

Yiliyasi Baikeli; Xamxikamar Mamat; Fei He; Xuelei Xin; Yongtao Li; Haji Akbar Aisa; Guangzhi Hu

doi:10.1016/j.ecoenv.2020.111066

Electrochemical determination of chloramphenicol and metronidazole by using a glassy carbon electrode modified with iron, nitrogen co-doped nanoporous carbon derived from a metal-organic framework (type Fe/ZIF-8)

Ecotoxicol Environ Saf. 2020 Nov:204:111066. doi: 10.1016/j.ecoenv.2020.111066. Epub 2020 Aug 8.

Authors

Yiliyasi Baikeli¹, Xamxikamar Mamat², Fei He², Xuelei Xin², Yongtao Li², Haji Akbar Aisa³, Guangzhi Hu⁴

Affiliations

¹ Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
² Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
³ Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. Electronic address: haji@ms.xjb.ac.cn.
⁴ Key Laboratory of Chemistry of Plant Resources in Arid Regions, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; Institute for Ecological Research and Pollution Control of Plateau Lakes, School of Ecology and Environmental Science,Yunnan University, Kunming, 650504, China. Electronic address: guangzhihu@ynu.edu.cn.

PMID: 32781344
DOI: 10.1016/j.ecoenv.2020.111066

Abstract

In this study, an iron-doped metal-organic framework (MOF) Fe/ZIF-8 was synthesized from ZIF-8 at room temperature. Direct carbonization of Fe/ZIF-8 under a nitrogen atmosphere produced nanoporous nitrogen doped carbon nanoparticles decorated with Fe component (Fe/NC). The Fe/NC exhibited a large surface area (1221.185 m² g^-1) and narrow pore-size distribution (3-5 nm). The nanoporous Fe/NC components along with Nafion were used to modify a glassy carbon electrode for the electrochemical determination of chloramphenicol and metronidazole via linear sweep voltammetry. Under optimal conditions, the reduction peak currents (observed at -0.237 V and -0.071 V vs. Ag/AgCl) of these analytes increased linearly with increasing chloramphenicol and metronidazole concentrations in the range of 0.1-100 μM and 0.5-30 μM, with the detection limits estimated to be 31 nM and 165 nM, respectively. This result was attributed to the large surface area, porous structure, high nitrogen content, and as well as the electrocatalytic effect of Fe atoms embeded in the carbon support. The proposed sensor was used for chloramphenicol and metronidazole analysis in samples, providing satisfactory results.

Keywords: Chloramphenicol; Electrochemical sensor; Metal-organic frameworks; Metronidazole; Modified glassy carbon; ZIF-8.

MeSH terms

Animals
Carbon / chemistry*
Chloramphenicol / analysis*
Chloramphenicol / urine
Electrochemical Techniques / methods*
Electrodes
Humans
Iron / chemistry*
Limit of Detection
Metal-Organic Frameworks / chemistry*
Metronidazole / analysis*
Metronidazole / urine
Milk / chemistry
Nanopores
Nitrogen / chemistry*
Ophthalmic Solutions / chemistry
Porosity
Tablets / chemistry

Substances

Metal-Organic Frameworks
Ophthalmic Solutions
Tablets
Metronidazole
Chloramphenicol
Carbon
Iron
Nitrogen