RUN-UP: Accelerated multishot diffusion-weighted MRI reconstruction using an unrolled network with U-Net as priors

Magn Reson Med. 2021 Feb;85(2):709-720. doi: 10.1002/mrm.28446. Epub 2020 Aug 11.


Purpose: To accelerate and improve multishot diffusion-weighted MRI reconstruction using deep learning.

Methods: An unrolled pipeline containing recurrences of model-based gradient updates and neural networks was introduced for accelerating multishot DWI reconstruction with shot-to-shot phase correction. The network was trained to predict results of jointly reconstructed multidirection data using single-direction data as input. In vivo brain and breast experiments were performed for evaluation.

Results: The proposed method achieves a reconstruction time of 0.1 second per image, over 100-fold faster than a shot locally low-rank reconstruction. The resultant image quality is comparable to the target from the joint reconstruction with a peak signal-to-noise ratio of 35.3 dB, a normalized root-mean-square error of 0.0177, and a structural similarity index of 0.944. The proposed method also improves upon the locally low-rank reconstruction (2.9 dB higher peak signal-to-noise ratio, 29% lower normalized root-mean-square error, and 0.037 higher structural similarity index). With training data from the brain, this method also generalizes well to breast diffusion-weighted imaging, and fine-tuning further reduces aliasing artifacts.

Conclusion: A proposed data-driven approach enables almost real-time reconstruction with improved image quality, which improves the feasibility of multishot DWI in a wide range of clinical and neuroscientific studies.

Keywords: convolution neural network; multishot diffusion-weighted imaging; phase variation; unrolled network.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Artifacts
  • Brain / diagnostic imaging
  • Diffusion Magnetic Resonance Imaging*
  • Image Processing, Computer-Assisted
  • Reproducibility of Results