Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity

Physiology (Bethesda). 2020 Sep 1;35(5):348-357. doi: 10.1152/physiol.00010.2020.


The peripheral nervous system (PNS) plays crucial roles in physiology and disease. Neuro-effector communication and neuroplasticity of the PNS are poorly studied, since suitable models are lacking. The emergence of human pluripotent stem cells (hPSCs) has great promise to resolve this deficit. hPSC-derived PNS neurons, integrated into organ-on-a-chip systems or organoid cultures, allow co-cultures with cells of the local microenvironment to study neuro-effector interactions and to probe mechanisms underlying neuroplasticity.

Keywords: human pluripotent stem cells; neuroplasticity; organ-on-a-chip; organoids; peripheral neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Coculture Techniques
  • Humans
  • Induced Pluripotent Stem Cells / metabolism
  • Induced Pluripotent Stem Cells / physiology*
  • Lab-On-A-Chip Devices
  • Microfluidic Analytical Techniques / instrumentation
  • Neural Stem Cells / metabolism
  • Neural Stem Cells / physiology*
  • Neuroeffector Junction / metabolism
  • Neuroeffector Junction / physiology*
  • Neuronal Plasticity*
  • Organoids / physiology
  • Peripheral Nervous System / metabolism
  • Peripheral Nervous System / physiology*
  • Phenotype
  • Synaptic Transmission*