Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan

Physiology (Bethesda). 2020 Sep 1;35(5):338-347. doi: 10.1152/physiol.00013.2020.


There is an increased focus on treatments to extend the healthspan. There is solid evidence that exercise extends the healthspan, but other treatments, such as metformin and statins, are also gaining traction. If metformin and statins will be used to prolong healthspan, we must understand their effects in those free of disease and in combination with exercise.

Keywords: aerobic; mitochondria; pharmaceutical; treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control*
  • Exercise*
  • Health Status
  • Healthy Aging*
  • Heart Disease Risk Factors
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypoglycemic Agents / therapeutic use*
  • Metformin / therapeutic use*
  • Primary Prevention*
  • Protective Factors
  • Risk Assessment
  • Risk Reduction Behavior*


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypoglycemic Agents
  • Metformin