Stromal regulation of tumor-associated lymphatics

Abstract

Recent advances have identified a growing array of roles played by lymphatics in the tumor microenvironment, from providing a route of metastasis to immune modulation. The tumor microenvironment represents an exceptionally complex, dynamic niche comprised of a diverse mixture of cancer cells and normal host cells termed the stroma. This review discusses our current understanding of stromal elements and how they regulate lymphatic growth and functional properties in the tumor context.

Keywords: Cancer-associated fibroblast; Extracellular matrix; Immune; Interstitial flow; Lymphangiogenesis; Stroma.