Black esophagus: a syndrome of acute esophageal necrosis associated with active alcohol drinking

BMJ Open Gastroenterol. 2020 Aug;7(1):e000466. doi: 10.1136/bmjgast-2020-000466.

Abstract

Black esophagus, also known as acute esophageal necrosis (AEN) syndrome, is a rare entity characterized by patchy or diffuse circumferential black pigmentation of the esophageal mucosa from ischemic necrosis. It may present with life-threatening upper gastrointestinal hemorrhage resulting in high mortality in immunocompromised patients. Advanced age with multiple comorbidities compounded with compromised hemodynamic states are poor prognostic factors. Findings on laboratory work-up and radiological imaging are non-specific. After initial resuscitation, endoscopic evaluation and histological examination of esophageal biopsy are diagnostic. Early recognition and aggressive resuscitation are the fundamental principles for the management of AEN and better outcome of the disease. We report a case of a 56-year-old woman with diabetes mellitus, gastro-esophageal reflux disease, and active alcohol binging who presented with hematemesis and acute epigastric pain due to AEN. This case illustrates a rare etiology of AEN due to active alcohol drinking, which may be overlooked. Physician awareness about this etiology is important as early recognition and timely management may improve survival.

Keywords: alcohol-induced injury; endoscopy; erosive oesophagitis; gastro-oesophageal reflux disease; oesophageal lesions.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking / adverse effects*
  • Awareness
  • Endoscopy / methods
  • Esophageal Diseases / etiology*
  • Esophageal Diseases / pathology
  • Esophagus / abnormalities
  • Esophagus / blood supply
  • Esophagus / pathology*
  • Female
  • Gastroesophageal Reflux / complications
  • Gastrointestinal Hemorrhage / etiology*
  • Gastrointestinal Hemorrhage / therapy
  • Hematemesis / diagnosis
  • Hematemesis / etiology*
  • Humans
  • Male
  • Middle Aged
  • Necrosis / diagnosis*
  • Proton Pump Inhibitors / therapeutic use
  • Resuscitation / methods
  • Treatment Outcome

Substances

  • Proton Pump Inhibitors