Bacterial invaders drive CRC progression

Sci Signal. 2020 Aug 11;13(644):eabc4218. doi: 10.1126/scisignal.abc4218.


The oral bacterium Fusobacterium nucleatum is often found in colorectal cancer (CRC). In the 21 July 2020 issue of Science Signaling, Casasanta et al show that CRC cell-resident F. nucleatum promotes cytokine secretion that may potentiate tumor growth and metastatic progression in patients.

Publication types

  • Review
  • Comment

MeSH terms

  • Bodily Secretions
  • Cell Movement
  • Chemokine CXCL1
  • Colorectal Neoplasms*
  • Fusobacterium nucleatum*
  • Humans
  • Interleukin-8


  • CXCL1 protein, human
  • Chemokine CXCL1
  • Interleukin-8