Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

Frank L van de Veerdonk; Ilse J E Kouijzer; Aline H de Nooijer; Hans G van der Hoeven; Coen Maas; Mihai G Netea; Roger J M Brüggemann

doi:10.1001/jamanetworkopen.2020.17708

Outcomes Associated With Use of a Kinin B2 Receptor Antagonist Among Patients With COVID-19

JAMA Netw Open. 2020 Aug 3;3(8):e2017708. doi: 10.1001/jamanetworkopen.2020.17708.

Authors

Frank L van de Veerdonk^{1

2}, Ilse J E Kouijzer^{1

2}, Aline H de Nooijer¹, Hans G van der Hoeven³, Coen Maas⁴, Mihai G Netea^{1

2

5}, Roger J M Brüggemann^{2

6}

Affiliations

¹ Radboudumc Institute for Molecular Life Sciences, Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands.
² Radboudumc Center for Infectious Diseases, Nijmegen, the Netherlands.
³ Department of Intensive Care Medicine, Radboudumc, Nijmegen, the Netherlands.
⁴ Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
⁵ Life and Medical Sciences Institute, Department for Genomics & Immunoregulation, University of Bonn, Bonn, Germany.
⁶ Radboud Institute for Health Sciences, Department of Pharmacy, Radboudumc, Nijmegen, the Netherlands.

Abstract

This case-control study examines the association between receipt of the bradykinin 2 (B2) receptor antagonist icatibant and improved oxygenation in patients with coronavirus disease 2019 (COVID-19).

MeSH terms

Adult
Aged
Betacoronavirus
Bradykinin / analogs & derivatives*
Bradykinin / metabolism*
Bradykinin / therapeutic use
Bradykinin B2 Receptor Antagonists / therapeutic use*
COVID-19
COVID-19 Drug Treatment
Coronavirus Infections / drug therapy*
Coronavirus Infections / metabolism
Coronavirus Infections / virology
Female
Humans
Male
Middle Aged
Oxygen / blood
Pandemics
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / metabolism
Pneumonia, Viral / virology
Receptor, Bradykinin B2 / metabolism*
SARS-CoV-2

Substances

Bradykinin B2 Receptor Antagonists
Receptor, Bradykinin B2
icatibant
Oxygen
Bradykinin