A Geroscience Approach to Preventing Pathologic Consequences of COVID-19

J Interferon Cytokine Res. 2020 Sep;40(9):433-437. doi: 10.1089/jir.2020.29018.dou. Epub 2020 Aug 13.


The essential scope of the coronavirus infectious disease 2019 (COVID-19) pandemic is focused on developing effective treatments and vaccines for acute SARS-CoV-2 infection. There is also a critical need to develop interventions to prevent the complications of COVID-19, which occur with an alarming frequency in older adults. Since severe pathologic effects of infection occur with increasing age, COVID-19 falls under the geroscience concept that all diseases in older adults have a common and major underlying cause of declining function and resilience. Geroscience posits that manipulation of aging will simultaneously delay the appearance or severity of major diseases because they share the same risk factor: aging and the multiple processes involved in aging. Drug combinations that target multiple aging processes and the cytokine networks associated with them would not necessarily limit SARS-CoV-2 infection rates but would prevent severe pathologic consequences of the disease in older adults by maintaining a more youthful-like resilience to infection-related complications. A drug cocktail aimed at controlling cytokine actions would complement current clinical treatments and vaccine effectiveness for COVID-19 and serve as a prototype for future age-related infectious disease pandemics wherein the elderly population is especially vulnerable.

Keywords: COVID-19 complications; aging resilience; antiaging drug cocktail; cytokines; geroscience; interactive cytokines.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging / drug effects*
  • Aging / physiology
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / pathology*
  • Cytokines / blood
  • Humans
  • Pandemics
  • Physical Fitness / physiology
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / pathology*
  • SARS-CoV-2


  • Cytokines