Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules

S T Pals; A den Otter; F Miedema; P Kabel; G D Keizer; R J Scheper; C J Meijer

Evidence that leukocyte function-associated antigen-1 is involved in recirculation and homing of human lymphocytes via high endothelial venules

J Immunol. 1988 Mar 15;140(6):1851-3.

Authors

S T Pals¹, A den Otter, F Miedema, P Kabel, G D Keizer, R J Scheper, C J Meijer

Affiliation

¹ Department of Pathology, Free University, Amsterdam, The Netherlands.

PMID: 3279123

Abstract

We report the results of mAb inhibition studies of human lymphocyte-high endothelial venule interaction in vitro. These studies in which T cells from both normal donors and from a LFA-1-deficient patient were used indicate that in addition to a system of organ-specific 90-kDa "homing" receptors on lymphocytes, LFA-1 is also involved in lymphocyte recirculation and homing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antibodies, Monoclonal / immunology
Antigens, Surface / deficiency
Antigens, Surface / immunology
Antigens, Surface / physiology*
Cell Adhesion
Cell Movement*
Humans
Infant, Newborn
Lymphocyte Function-Associated Antigen-1
Organ Specificity
T-Lymphocytes / physiology*
Venules

Substances

Antibodies, Monoclonal
Antigens, Surface
Lymphocyte Function-Associated Antigen-1