Objective:To investigate the effects of nasal specific symptoms on chronic rhinosinusitis（CRS） with anxiety, depression and other psychological dysfunction and endoscopic surgery for the improvement of psychological dysfunction in patients with CRS. Method:The Hamilton Anxiety Scale（HAMA）, Hamilton Depression Scale（HAMD） and the 22-Item Sino-Nasal Outcome Test（SNOT-22） were completed in 44 patients with CRS within one week before and 6 months after surgery. They were used to assess mental function and nasal specific symptoms. Result:According to the SNOT-22 score, patients with anxiety and depression mental dysfunction had more severe symptoms of dizziness, head and face pain and sleep disorders（P<0.01 or P<0.05）. After endoscopic sinus surgery, the scores of HAMD, HAMA and SNOT-22 in CRS patients were improved compared with preoperative（P<0.01）. Conclusion:Patients with CRS have more common anxiety and depression. The specific symptoms of dizziness and head and face pain are significantly related to the psychological dysfunction of patients with CRS. Endoscopic sinus surgery can significantly alleviate the specific symptoms and mental dysfunction.
目的：探讨鼻部特异性症状可能影响慢性鼻窦炎（chronic rhinosinusitis，CRS）患者合并焦虑、抑郁等心理功能障碍的情况及鼻内镜手术对其心理功能障碍状况的改善。 方法：在术前1周内及术后6个月对44例CRS患者完成汉密顿焦虑情绪量表（Hamilton Anxiety Scale，HAMA）、汉密顿抑郁情绪量表（Hamilton Depression Scale，HAMD）及鼻腔鼻窦结局测量22条（the 22-Item Sino-Nasal Outcome Test，SNOT-22）评测，以评估其心理功能状态和鼻部特异性症状改善程度，同时随机选取同期体检的健康成人51例作为对照组。 结果：根据SNOT-22评分，合并焦虑、抑郁心理功能障碍的患者有更严重的头昏、头面部胀痛症状及睡眠障碍（P<0.01或P<0.05）。经功能性内镜鼻窦手术后，CRS患者HAMD、HAMA及SNOT-22评分较术前均有改善（P<0.01）。 结论：CRS患者合并焦虑、抑郁情况较为普遍，头昏、头面部胀痛特异性症状与CRS患者心理功能障碍关系显著，鼻内镜手术可显著缓解患者特异性症状和心理功能障碍。.
Keywords: anxiety; depression; sinusitis; specific symptoms.
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