Purging tumor cells from bone marrow by use of antibody and complement: a critical appraisal

J Natl Cancer Inst. 1988 Apr 6;80(3):154-9. doi: 10.1093/jnci/80.3.154.


This review highlighted several problems associated with the use of antibody and complement in the elimination of tumor cells from bone marrow that was to be used for transplantation, and it discussed some of the difficulties encountered in developing this approach in model systems. These problems should be seriously considered by any clinician contemplating this method for bone marrow purging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antibodies / immunology*
  • Bone Marrow / pathology
  • Bone Marrow Transplantation*
  • Complement System Proteins / immunology*
  • Cytotoxicity, Immunologic*
  • Humans
  • Neoplasms / immunology
  • Neoplasms / pathology*
  • Neoplasms / therapy


  • Antibodies
  • Complement System Proteins