Trace elements and oxidative stress status in patients with psoriasis

Postepy Dermatol Alergol. 2020 Jun;37(3):333-339. doi: 10.5114/ada.2020.94265. Epub 2020 Apr 7.


Introduction: Psoriasis is a common, inflammatory skin disease of which etiopathogenesis is still not explained clearly, however in which trace elements and oxidative stress are considered to play a role.

Aim: To evaluate the serum trace element and oxidative stress levels in patients diagnosed with psoriasis.

Material and methods: A total of 87 psoriasis patients and 60 healthy subjects were included in the study. Serum sodium (Na), potassium (K), calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe), selenium (Se), zinc (Zn), copper (Cu) levels, oxidative stress parameters, ischemia-modified albumin (IMA), catalase (CAT), myeloperoxidase (MPO) and ferroxidase (FOX) activity and an inflammatory marker, C-reactive protein (CRP), were examined in all participants.

Results: IMA, IMA/Albumin (IMA/Alb), CAT, Cu, FOX and CRP levels were found to be significantly higher; Se, Zn and albumin levels were significantly lower in the patient group as compared to the control group. No significant difference was found between groups with regard to Na, K, Ca, P, Mg, Fe and MPO levels.

Conclusions: Some trace element levels and oxidant-antioxidant balance were changed in psoriasis patients.

Keywords: copper; ischemia-modified albumin; psoriasis; selenium; trace element; zinc.