Mitochondrial metabolism and cancer metastasis

Dandan Yu; Chang Liu; Ling Guo

doi:10.21037/atm.2020.03.42

Mitochondrial metabolism and cancer metastasis

Ann Transl Med. 2020 Jul;8(14):904. doi: 10.21037/atm.2020.03.42.

Authors

Dandan Yu^{1

2}, Chang Liu^{1

3}, Ling Guo¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Academy for Advanced Interdisciplinary Studies, and Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
² Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China.
³ Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China.

Abstract

Metastasis is regarded as the most important cause of cancer-related deaths around the world. During the complicated metastatic cascade, altered mitochondrial metabolism adapts to serve distinct conditions and microenvironments. In this review, we discuss how cells regulate their mitochondria metabolism to adapt to environmental cues during the metastasis, as well as how cancer cells and their tumor micro-environment (TME) are metabolically coupled during the metastatic cascade. We place a strong emphasis on how mitochondrial proline metabolism and extracellular matrix (ECM) are coupled.

Keywords: Metastasis; extracellular matrix (ECM); mitochondrial metabolism; proline metabolism; tumor micro-environment (TME).

Publication types

Review