Familial clustering of COVID-19 skin manifestations

Dermatol Ther. 2020 Nov;33(6):e14181. doi: 10.1111/dth.14181. Epub 2020 Sep 4.


The medical community in the past months has seen a flourishing of information related to the SARS-CoV-2 virus responsible for the COVID-19 pandemic. From the early days of the pandemic, the SARS-CoV-2 virus has been linked to multiple different types of skin involvement. To the best of our knowledge, we are the first to report on a case of familial clustering of a maculopapular COVID-19 rash. Eight persons presented COVID-19 symptoms, six were confirmed via SAR-CoV-2 chemoluminescent immunoassays, and the four related by blood presented skin manifestations. Although, it has not been fully established if the SARS-CoV-2 can in fact cause viral exanthems, our observations regarding the familial clustering and the temporal evolution seen in this family seem to present strong evidence of a viral exanthema related to SARS-CoV-2 infection.

Keywords: COVID-19; familial clustering; genetics; immunology; virology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged, 80 and over
  • COVID-19 / complications*
  • COVID-19 / diagnosis
  • COVID-19 Testing*
  • Family Health
  • Female
  • Humans
  • Infant
  • Luminescent Measurements
  • Male
  • Middle Aged
  • SARS-CoV-2 / isolation & purification
  • Skin Diseases, Viral / diagnosis*
  • Skin Diseases, Viral / physiopathology