Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis

Circulation. 2020 Aug 18;142(7):708-710. doi: 10.1161/CIRCULATIONAHA.120.047911. Epub 2020 Jun 22.

Abstract

Supplemental Digital Content is available in the text.

Keywords: COVID-19; cardiovascular diseases; heart; myocarditis; severe acute respiratory syndrome coronavirus 2.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus / isolation & purification
  • Betacoronavirus / pathogenicity
  • COVID-19
  • Cardiomyopathy, Dilated / genetics
  • Cardiomyopathy, Dilated / pathology
  • Cardiomyopathy, Hypertrophic / genetics
  • Cardiomyopathy, Hypertrophic / pathology
  • Cathepsin L / genetics
  • Cathepsin L / metabolism
  • Coronavirus Infections / complications
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / virology
  • Heart Ventricles / metabolism
  • Humans
  • Myocarditis / diagnosis*
  • Myocarditis / etiology
  • Myocardium / metabolism*
  • Pandemics
  • Peptidyl-Dipeptidase A / chemistry
  • Peptidyl-Dipeptidase A / genetics*
  • Peptidyl-Dipeptidase A / metabolism
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / virology
  • Protease Inhibitors / pharmacology
  • RNA-Seq
  • SARS-CoV-2
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism
  • Up-Regulation / drug effects

Substances

  • Protease Inhibitors
  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human
  • CTSL protein, human
  • Cathepsin L