Abstract
Although T cells are considered as the central component in immune-mediated diseases, supportive evidence has demonstrated that B cells also contribute to the progression of these diseases. B cells are divided into various subsets according to their secreted cytokines. Different B cell subsets play diverse roles in immune-mediated dermatoses. Regulatory B cells (Bregs) are defined functionally by their ability to secrete IL-10, which has been revealed to contribute to immunological tolerance. Drugs that deplete B cells, such as rituximab, are now used for the treatment of several immune-mediated dermatoses. In this review, we present and discuss the current knowledge on the roles of B cells in several immune-mediate dermatoses including psoriasis, pemphigus, bullous pemphigoid, and dermatomyositis, atopic dermatitis.
Keywords:
B cells; Pemphigus; Psoriasis; Regulatory B cells.
Copyright © 2020. Published by Elsevier Ltd.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
B-Lymphocytes, Regulatory / drug effects
-
B-Lymphocytes, Regulatory / immunology*
-
B-Lymphocytes, Regulatory / metabolism
-
Dermatitis, Atopic / blood
-
Dermatitis, Atopic / drug therapy
-
Dermatitis, Atopic / immunology*
-
Dermatitis, Atopic / pathology
-
Dermatomyositis / blood
-
Dermatomyositis / drug therapy
-
Dermatomyositis / immunology*
-
Dermatomyositis / pathology
-
Desmoglein 3 / metabolism
-
Disease Models, Animal
-
Humans
-
Immunologic Factors / pharmacology
-
Immunologic Factors / therapeutic use
-
Interleukin-10 / metabolism
-
Lymphocyte Depletion / methods
-
Pemphigoid, Bullous / blood
-
Pemphigoid, Bullous / drug therapy
-
Pemphigoid, Bullous / immunology*
-
Pemphigoid, Bullous / pathology
-
Pemphigus / blood
-
Pemphigus / drug therapy
-
Pemphigus / immunology*
-
Pemphigus / pathology
-
Psoriasis / blood
-
Psoriasis / drug therapy
-
Psoriasis / immunology*
-
Psoriasis / pathology
-
Skin / immunology
-
Skin / pathology
Substances
-
Desmoglein 3
-
Immunologic Factors
-
Interleukin-10