Emerging therapeutics for the management of COVID 19

Expert Opin Emerg Drugs. 2020 Sep;25(3):337-351. doi: 10.1080/14728214.2020.1810663. Epub 2020 Sep 8.

Abstract

Introduction: The coronavirus-19 (COVID-19) disease pandemic can be characterized as the most critical and changeable hazard to healthcare systems in eras. The high fatality rate associated with coronavirus infection underlines the urgent need for an effective treatment to reduce disease severity and mortality.

Areas covered: A detailed search for treatments related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) was carried out using PubMed. Components of the virus relevant to the infectious mechanism were identified. We have highlighted all the latest emerging and repurposed drugs that were found to be active against this novel coronavirus and classified these drugs according to their category. Different drug targets are discussed in order to identify new molecules or new combinations as candidates to manage SARS-CoV2/COVID-19 infections.

Expert opinion: The development of novel molecules and vaccines has been a challenge during this urgent crisis. Nucleoside analogs and IL-6 receptor antagonists have been identified as the best candidates for treatment of this disease. Multi-drug therapy by targeting different pathways will need to be corroborated and then confirmed through clinical trials. Until a vaccine is available, an alternative drug regimen needs to be adopted by clinicians in the management of coronavirus symptoms.

Keywords: Covid-19; SARS-CoV-2; drugs; structure; therapeutics; vaccine.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anticoagulants / administration & dosage
  • Antiviral Agents / administration & dosage*
  • Betacoronavirus / drug effects*
  • Betacoronavirus / physiology
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / drug therapy*
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / therapy
  • Disease Management*
  • Drug Design*
  • Humans
  • Immunization, Passive
  • Pandemics
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / drug therapy*
  • Pneumonia, Viral / epidemiology
  • Vasodilator Agents / administration & dosage
  • Viral Vaccines / administration & dosage

Substances

  • Anti-Inflammatory Agents
  • Anticoagulants
  • Antiviral Agents
  • Vasodilator Agents
  • Viral Vaccines

Supplementary concepts

  • COVID-19
  • COVID-19 serotherapy
  • severe acute respiratory syndrome coronavirus 2