Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim; Dong-Hwa Cho; Dong-Keon Kweon; Eun-Hee Jang; Joo-Yeon Hong; Seung-Taik Lim

doi:10.1007/s10068-020-00771-1

Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Food Sci Biotechnol. 2020 May 27;29(9):1233-1239. doi: 10.1007/s10068-020-00771-1. eCollection 2020 Sep.

Authors

Seulki Kim¹, Dong-Hwa Cho¹, Dong-Keon Kweon², Eun-Hee Jang², Joo-Yeon Hong², Seung-Taik Lim¹

Affiliations

¹ Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 South Korea.
² Jinwoo Bio Co., Ltd., Seoul, 02455 South Korea.

Abstract

Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

Keywords: Carboxymethyl cellulose; Disintegration time; Low molecular hyaluronic acid; Mechanical properties; Orodispersible film.