Olfactory function deteriorates in patients with Parkinson's disease complicated with REM sleep behavior disorder

Takashi Nomura; Yuki Nomura; Masayoshi Oguri; Yasuaki Hirooka; Ritsuko Hanajima

doi:10.1016/j.ensci.2020.100261

Olfactory function deteriorates in patients with Parkinson's disease complicated with REM sleep behavior disorder

eNeurologicalSci. 2020 Aug 3:20:100261. doi: 10.1016/j.ensci.2020.100261. eCollection 2020 Sep.

Authors

Takashi Nomura¹, Yuki Nomura¹, Masayoshi Oguri², Yasuaki Hirooka², Ritsuko Hanajima³

Affiliations

¹ Nomura Neuro Sleep Clinic, Yonago, Japan.
² Department of Pathobiological Science and Technology, School of Health Science, Faculty of Medicine, Tottori University, Yonago, Japan.
³ Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.

Abstract

Introduction: It is not concluded whether the association between olfactory dysfunction and REM sleep behavior disorder (RBD) were worsen cognitive function in patients with Parkinson's disease (PD). We sought to evaluate the impact of these symptoms in PD.

Methods: We examined 62 patients with PD using an olfactory test (Odor Stick Identification Test for Japanese: OSIT-J) and polysomnography (PSG). We divided the patients into 3 groups: PD with clinical RBD (n = 32), PD with subclinical RBD (n = 11), and PD with normal REM sleep (n = 19). We compared their clinical backgrounds, results of OSIT-J, autonomic functions, and cognitive functions such as Montreal cognitive assessment Japanese version (MoCA-J). Some factors associated with RBD were analyzed by multiple regression.

Results: There were significant differences in the results of OSIT-J, and autonomic and cognitive functions between the 3 groups. There were significant differences in the total OSIT-J score between the 3 groups (PD with clinical RBD: 3.3 ± 2.2, PD with subclinical RBD: 4.0 ± 2.6, PD with normal REM sleep: 6.7 ± 3.0, p < 0.001). Patients in the group with PD with clinical RBD had a significantly lower score than those with normal REM sleep (p < 0.001). Logistic regression analysis showed that OSIT-J score was significantly associated with RBD. The PD group with clinical RBD had more patients with mild cognitive impairment than the group with normal REM sleep. Multiple regression analysis revealed that olfactory dysfunction was correlated with MoCA-J.

Conclusions: Olfactory dysfunction is associated with RBD. Especially, it is important to screen olfactory function in RBD complicated patients with PD in view of cognitive impairment.

Keywords: Cognitive impairment; OSIT-J; PD; RBD.