Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion

Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111158. doi: 10.1016/j.msec.2020.111158. Epub 2020 Jun 20.

Abstract

In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.

Keywords: Alveolar ridge preservation; Injectable hydrogel; Nano-hydroxyapatite; Osteogenesis; Soft tissue healing.

MeSH terms

  • Alveolar Process
  • Animals
  • Bone Regeneration*
  • Durapatite*
  • Hydrogels* / pharmacology
  • Rats
  • Tooth Extraction
  • Tooth Socket

Substances

  • Hydrogels
  • Durapatite