Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study

Nutrients. 2020 Aug 12;12(8):2417. doi: 10.3390/nu12082417.


Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-µg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.

Keywords: Japan; cohort; dietary acrylamide; lung cancer.

Publication types

  • Evaluation Study

MeSH terms

  • Acrylamide / adverse effects
  • Acrylamide / analysis*
  • Adult
  • Aged
  • Carcinogens / analysis*
  • Diet / adverse effects*
  • Diet Surveys
  • Female
  • Humans
  • Incidence
  • Japan / epidemiology
  • Lung Neoplasms / epidemiology*
  • Lung Neoplasms / etiology
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Prospective Studies
  • Public Health / statistics & numerical data*


  • Carcinogens
  • Acrylamide