Postmenopausal Syndrome

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.


Menopause is defined as the permanent cessation of menstruation. The diagnosis is made retrospectively after menstruation is absent for 12 months. Most women enter menopause between the ages of 49 and 52 years, and the average age among women in the United States is 51 years. Menopause before the age of 40 years is defined as premature menopause. Women spend one-third of their life in the postmenopausal stage. It represents a primary ovarian failure where there is a depletion of ovarian follicles, the primary source of estrogen. The majority of symptoms are due to estrogen deficiency. But it is difficult to distinguish it from those related to aging.

The health concerns among menopausal women are mainly related to vasomotor symptoms, urogenital atrophy, osteoporosis, cardiovascular disease, cancer, psychiatric symptoms, cognitive decline, and sexual problems. It is important to understand the associated risk factors, clinical presentation, and the management of common menopausal symptoms for improved patient care and health outcomes for older female patients. The four core symptoms- hot flashes, poor sleep, genitourinary symptoms/sexual dysfunction, and mood changes were most commonly seen among menopausal women are referred to as postmenopausal syndrome.

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