A guide to plasma membrane solute carrier proteins

FEBS J. 2021 May;288(9):2784-2835. doi: 10.1111/febs.15531. Epub 2020 Sep 18.


This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC superfamily currently includes 458 transport proteins in 65 families that carry a wide variety of substances across cellular membranes. While members of this superfamily are found throughout cellular organelles, this review focuses on transporters expressed at the plasma membrane. At the cell surface, SLC proteins may be viewed as gatekeepers of the cellular milieu, dynamically responding to different metabolic states. With altered metabolism being one of the hallmarks of cancer, we also briefly review the roles that surface SLC proteins play in the development and progression of cancer through their influence on regulating metabolism and environmental conditions.

Keywords: amino acids; cancer; cell surface; cellular metabolism; cellular transport; glucose; pH; physiology; plasma membrane; solute carrier transporter.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport / genetics*
  • Cell Membrane / genetics
  • Humans
  • Membrane Transport Proteins / genetics*
  • Neoplasms / genetics*
  • Solute Carrier Proteins / genetics*


  • Membrane Transport Proteins
  • Solute Carrier Proteins