Childhood asthma increases respiratory morbidity, but not all-cause mortality in adulthood: The Busselton Health Study

Respir Med. 2020 Sep;171:106095. doi: 10.1016/j.rmed.2020.106095. Epub 2020 Jul 28.

Abstract

Background: Long-term childhood asthma studies that investigate adult outcomes other than lung function are lacking. This study examines the associations of childhood asthma and the occurrence of respiratory events and all-cause mortality in adulthood.

Methods: A cohort of 4430 school children (aged to 17 years) who attended the Busselton Health Study between 1967 and 1983 were analysed. Self-reported history of asthma was determined using questionnaires. Participants were followed until 2014 for respiratory disease-related events (hospital admissions or death) and all-cause mortality using the Western Australia Data Linkage System. Cox regression models were used to investigate the impact of childhood asthma on respiratory events and all-cause mortality in adulthood. A subgroup of 2153 participants who re-attended a survey in young adulthood was also analysed.

Results: A total of 462 (10%) of the cohort had childhood asthma. During follow-up 791 participants experienced a respiratory event and 140 participants died. Childhood asthma was associated with an increased risk of respiratory events in adulthood (unadjusted HR 1.84, 95% CI 1.52 to 2.23; P < 0.0001). The result remained significant after adjusting for adult-onset asthma, FEV1, body mass index, smoking, dusty job, hay fever, and respiratory symptoms (adjusted HR 1.68, 95% CI 1.07 to 2.64; P = 0.0247). Childhood asthma was not associated with all-cause mortality in adulthood (unadjusted HR 1.08, 95% CI 0.63 to 1.84; P = 0.7821).

Conclusion: Childhood asthma is associated with increased risk of respiratory disease-related hospital admissions and death but not all-cause mortality in adulthood.

Keywords: Asthma; Childhood; Cohort study; Morbidity; Mortality; Respiratory diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Age of Onset
  • Asthma / complications*
  • Asthma / epidemiology
  • Cause of Death
  • Child
  • Cohort Studies
  • Female
  • Hospitalization / statistics & numerical data*
  • Humans
  • Male
  • Morbidity
  • Respiratory Tract Diseases / epidemiology
  • Respiratory Tract Diseases / etiology*
  • Respiratory Tract Diseases / mortality
  • Risk
  • Young Adult