25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor

Cell Res. 2020 Nov;30(11):1043-1045. doi: 10.1038/s41422-020-00398-1. Epub 2020 Aug 18.

Shulong Zu^#^{1

2

3}, Yong-Qiang Deng^#³, Chao Zhou^#³, Jie Li^#⁴, Lili Li^{1

2}, Qi Chen³, Xiao-Feng Li³, Hui Zhao³, Sarah Gold⁵, Jun He⁶, Xiang Li⁷, Changqing Zhang⁸, Heng Yang^{9

10}, Genhong Cheng¹¹, Cheng-Feng Qin¹²

¹ Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
² Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, 215123, China.
³ Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China.
⁴ Department of Laboratory Medicine, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
⁵ Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
⁶ Institute of Laboratory Animal Sciences, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100050, China.
⁷ Porton (Shanghai) R&D Center, Shanghai, 200241, China.
⁸ CoSci Med-Tech Co., Ltd, Beijing, 100083, China.
⁹ Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. yhmyt@hotmail.com.
¹⁰ Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, 215123, China. yhmyt@hotmail.com.
¹¹ Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, 90095, USA. gcheng@mednet.ucla.edu.
¹² Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, China. qincf@bmi.ac.cn.

^# Contributed equally.

No abstract available

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