Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus

Yuka Kobayashi; Ryo Suzuki; Keiko Yasukawa; Koji Oba; Toshimasa Yamauchi; Yutaka Yatomi; Takashi Kadowaki

doi:10.1016/j.metop.2020.100032

Oxidized albumin in blood reflects the severity of multiple vascular complications in diabetes mellitus

Metabol Open. 2020 Mar 14:6:100032. doi: 10.1016/j.metop.2020.100032. eCollection 2020 Jun.

Authors

Yuka Kobayashi¹, Ryo Suzuki^{1

2}, Keiko Yasukawa³, Koji Oba⁴, Toshimasa Yamauchi¹, Yutaka Yatomi³, Takashi Kadowaki^{1

5}

Affiliations

¹ Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Department of Diabetes, Metabolism and Endocrinololy, Tokyo Medical University, Tokyo, Japan.
³ Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
⁴ Graduate School of Interdisciplinary Information Studies, Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
⁵ Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Abstract

Albumin has an oxidized form, known as non-mercaptalbumin (HNA), which reflects systemic oxidative stress. The association between serum HNA levels and diabetic complications are yet to be reported. In this cross-sectional study, we investigated 164 diabetic subjects to assess the correlation between HNA% (the proportion in the total albumin) and various clinical parameters. HNA% was significantly associated with the severity of multiple complications including neuropathy (23.3 ± 4.1% vs 26.2 ± 5.1%) and nephropathy (24.1 ± 3.9%, 24.6 ± 4.2%, 28.5 ± 6.1%, 31.3 ± 5.7%, 37.8 ± 2.9%, stage 1/2/3/4/5, respectively). These findings highlight the universal importance of oxidative stress, indicating HNA% potential as a versatile marker of the severity of diabetic complications.

Keywords: Diabetic complication; HNA%; Nephropathy; Neuropathy; Oxidative stress; Retinopathy.