YAP/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways

Mol Cell Biochem. 2020 Dec;475(1-2):137-149. doi: 10.1007/s11010-020-03866-9. Epub 2020 Aug 19.

Abstract

YAP and TAZ are important co-activators of various biological processes in human body. YAP/TAZ plays a vital role in the development of pulmonary fibrosis. Dysregulation of the YAP/TAZ signaling pathway is one of the most important causes of pulmonary fibrosis. Therefore, considering its crucial role, summary of the signal mechanism of YAP/TAZ is of certain guiding significance for the research of YAP/TAZ as a therapeutic target. The present review provided a detailed introduction to various YAP/TAZ-related signaling pathways and clarified the specific role of YAP/TAZ in these pathways. In the meantime, we summarized and evaluated possible applications of YAP/TAZ in the treatment of pulmonary fibrosis. Overall, our study is of guiding significance for future research on the functional mechanism of YAP/TAZ underlying lung diseases as well as for identification of novel therapeutic targets specific to pulmonary fibrosis.

Keywords: Clinical treatment; Pulmonary fibrosis; Signaling pathway; YAP/TAZ.

Publication types

  • Review