Pancreatic cancer SLUGged

Rachel H Josselsohn; David A Tuveson

doi:10.1084/jem.20200819

Pancreatic cancer SLUGged

J Exp Med. 2020 Sep 7;217(9):e20200819. doi: 10.1084/jem.20200819.

Authors

Rachel H Josselsohn^{1

2

3}, David A Tuveson^{1

2}

Affiliations

¹ Cancer Center at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
² Lustgarten Foundation Dedicated Laboratory at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
³ Donald and Barbara Zucker School of Medicine at Hofstra University and Northwell Health, Hempstead, NY.

Abstract

In this issue of JEM, Recouvreux et al. (https://doi.org/10.1084/jem.20200388) describe the role of nutrient sensing in the induction of epithelial-mesenchymal transition. Glutamine-deficient pancreatic cancer cells up-regulate classic EMT regulator Slug, providing a link between nutrient stress and metastasis.

Publication types

Comment

MeSH terms

Animals
Cell Line, Tumor
Epithelial-Mesenchymal Transition
Gastropoda*
Glutamine
Pancreatic Neoplasms*

Substances

Glutamine