Scratching Beyond the Surface of Itchy Wounds

Immunity. 2020 Aug 18;53(2):235-237. doi: 10.1016/j.immuni.2020.07.016.


In this issue of Immunity, Xu et al. reveal that dermal dendritic cells produce interleukin-31, which acts on neurons to promote wound itch. Their findings link itch associated with deeper wounds-wounds that extend beyond the epithelium-to the cells and cytokines that mediate wound healing.

Publication types

  • Comment

MeSH terms

  • Cytokines*
  • Humans
  • Interleukins
  • Langerhans Cells
  • Pruritus
  • Sensory Receptor Cells
  • Transforming Growth Factor beta*


  • Cytokines
  • Interleukins
  • Transforming Growth Factor beta