Gut Feelings Block the Flow: Microbiota Links Stress to Vascular Disease

Xue-Yan He; David Ng; Mikala Egeblad

doi:10.1016/j.immuni.2020.07.013

Gut Feelings Block the Flow: Microbiota Links Stress to Vascular Disease

Immunity. 2020 Aug 18;53(2):238-240. doi: 10.1016/j.immuni.2020.07.013.

Authors

Xue-Yan He¹, David Ng¹, Mikala Egeblad²

Affiliations

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: egeblad@cshl.edu.

PMID: 32814021
DOI: 10.1016/j.immuni.2020.07.013

Abstract

Stress is linked to negative outcomes in cardiovascular diseases but exactly why is unclear. In this issue of Immunity, Xu et al. report that stress elicits glucocorticoid-induced gut permeability, in turn triggering the expansion of a population of neutrophils that can stimulate vaso-occlusive episodes.

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MeSH terms

Emotions
Gastrointestinal Microbiome*
Humans
Inflammation
Microbiota*
Vascular Diseases*