The Persistence of Privilege for a Healthy Retina

Immunity. 2020 Aug 18;53(2):240-242. doi: 10.1016/j.immuni.2020.07.022.


A minor haplotype of chromosome 10q26 accounts for much of the genetic risk of age-related macular degeneration (AMD). In this issue of Immunity, Beguier et al. demonstrate that carriers of the 10q26 AMD-risk haplotype overexpress the peptidase HTRA1, which in turns results in mononuclear phagocyte persistence in an immune privileged site and pathogenic inflammation.

Publication types

  • Comment

MeSH terms

  • Haplotypes
  • High-Temperature Requirement A Serine Peptidase 1
  • Humans
  • Inflammation
  • Macular Degeneration* / genetics
  • Monocytes*
  • Proteins
  • Retina
  • Serine Endopeptidases / genetics


  • Proteins
  • High-Temperature Requirement A Serine Peptidase 1
  • HtrA1 protein, human
  • Serine Endopeptidases