First Trimester Prenatal Diagnosis of a Conotruncal Anomaly Using Spatiotemporal Image Correlation Imaging Confirmed by Conventional Autopsy

Fetal Pediatr Pathol. 2022 Apr;41(2):346-350. doi: 10.1080/15513815.2020.1806419. Epub 2020 Aug 20.


BackgroundFetal echocardiography continues to be the first line investigation for detecting congenital heart diseases (CHD). As accurate and complete diagnosis of complex heart disease is often difficult in the first trimester due to small size of the fetal heart, confirmation/expanded description by fetopsy provides the best information for accurate counseling for future pregnancies. Although non invasive fetal autopsy alternatives have been investigated with favorable results, conventional autopsy remains the gold standard procedure used to confirm the fetal abnormalities. Case report: We describe a conotruncal anomaly diagnosed at 12 weeks gestation using spatiotemporal image. The fetopsy confirmed the diagnosis of Type I Truncus arteriosus. Conclusion: Four-dimensional STIC imaging provides incremental benefits in evaluation of fetal cardiac anomalies, and confirmation by autopsy findings allows further refinement of the diagnosis.

Keywords: Fetus; Truncus arteriosus; conventional autopsy; first trimester; spatiotemporal image correlation imaging.

Publication types

  • Case Reports

MeSH terms

  • Autopsy
  • Echocardiography, Four-Dimensional* / methods
  • Female
  • Heart Defects, Congenital* / diagnostic imaging
  • Humans
  • Pregnancy
  • Pregnancy Trimester, First
  • Prenatal Diagnosis
  • Ultrasonography, Prenatal / methods