Evaluation of familial Mediterranean fever patients concomitant with juvenile spondyloarthropathy

Mod Rheumatol. 2021 May;31(3):718-724. doi: 10.1080/14397595.2020.1812809. Epub 2020 Sep 7.


Objectives: Familial Mediterranean fever (FMF) may present with various concomitant diseases. This study aims to evaluate the clinical characteristics of patients with FMF with Juvenile Spondyloarthropathy (jSpA).

Method: Thirty-two patients diagnosed with FMF/jSpA, sixty-four with FMF, and fifty-four with jSpA were included in this retrospective study. Three patient groups were compared in terms of clinical and laboratory features.

Results: The mean ages of patients in the FMF/jSpA, FMF and jSpA groups were 15.75(11.50-19.83), 15,41(6.83-21.50), and 16(9-22) years, respectively. Chronic arthritis (OR: 0.11, p = .049), erythrocyte sedimentation rate values (OR:1.07, p = .011), and C-reactive protein values (OR:1,08, p: .039) of the patients in remission period were found higher, the international severity scores for FMF (ISSF) before and after colchicine treatment (OR: 1.16, p: .021, OR: 2,21, p: .012) were higher in the FMF/jSpA group compared to FMF. Plantar fasciitis was more common and HLA-B27 positivity rate was lower in the FMF/jSpA group (OR:0.08, p = .024), (OR:4.71, p = .002) compared to jSpA. FMF/jSpA patients were divided as previous diagnosed FMF and jSpA.The diagnosis of jSpA was at a younger age(p = .002), Juvenile arthritis damage index-articular(p = 0.022) and extraarticular(p = .026), and the rate of biologic drug usage(p = .015) were higher in the previous jSpA group. The number of FMF attacks before colchicine was lower in the previous jSpA group(p = .02).

Conclusion: Our findings suggest that both classical FMF and jSpA findings were lower in patients with FMF/jSpA. Patients who were diagnosed with jSpA at an early age and who had enthesitis and plantar fasciitis should also be evaluated in terms of FMF.

Keywords: Children; familial Mediterranean fever (FMF); spondyloarthropathy.

MeSH terms

  • Adolescent
  • Adult
  • Arthritis, Juvenile / complications*
  • Arthritis, Juvenile / diagnosis
  • Blood Sedimentation
  • C-Reactive Protein
  • Familial Mediterranean Fever / complications*
  • Familial Mediterranean Fever / diagnosis
  • Female
  • Humans
  • Male
  • Spondylitis, Ankylosing / complications*
  • Spondylitis, Ankylosing / diagnosis


  • C-Reactive Protein