DREIMT: a drug repositioning database and prioritization tool for immunomodulation

Bioinformatics. 2021 May 1;37(4):578-579. doi: 10.1093/bioinformatics/btaa727.


Motivation: Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases.

Results: DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables.

Availabilityand implementation: http://www.dreimt.org.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Databases, Factual
  • Databases, Pharmaceutical
  • Drug Repositioning*
  • Immunomodulation
  • Transcriptome*