"The One Who Guides" Nigral Neuron Migration

Rajeshwar Awatramani; Martin Lévesque

doi:10.1016/j.neuron.2020.07.030

"The One Who Guides" Nigral Neuron Migration

Neuron. 2020 Aug 19;107(4):595-596. doi: 10.1016/j.neuron.2020.07.030.

Authors

Rajeshwar Awatramani¹, Martin Lévesque²

Affiliations

¹ Northwestern University, Department of Neurology, Chicago, IL 60611, USA. Electronic address: r-awatramani@northwestern.edu.
² Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval, CERVO Brain Research Centre, 2601 Chemin de la Canardiere, Quebec, QC, Canada.

PMID: 32818472
DOI: 10.1016/j.neuron.2020.07.030

Abstract

In this issue, Brignani, Raj, et al. show that Netrin-1 from distinct sources controls neuronal migrations into the substantia nigra. Remarkably, one source of Netrin -1 is forebrain axons traversing the midbrain, and this is required for proper GABAergic neuronal migration into the substantia nigra pars reticulata.

Publication types

Comment

MeSH terms

Axons
Dopamine
GABAergic Neurons*
Netrin-1
Substantia Nigra*

Substances

Netrin-1
Dopamine