Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

J Mol Cell Cardiol. 2020 Oct:147:88-91. doi: 10.1016/j.yjmcc.2020.08.009. Epub 2020 Aug 18.

¹ Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University, The Netherlands and Laboratory of Experimental Cardiology, Dept. of Cardiovascular Sciences, KU Leuven, Campus Gasthuisberg, Herestraat 49, Leuven B-3000, Belgium.
² Karolinska Institutet, BioClinicum, Oncology and Pathology, The National Board of Forensic Medicine, SE-17177 Stockholm, Stockholm, Sweden.
³ Center for Regenerative Therapies Dresden, TU-Dresden, Fetscherstrasse 105, Dresden 01307, Germany.; Karolinska Institutet, Biomedicum, Cell and Molecular Biology, SE-17177, Stockholm, Sweden.
⁴ Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
⁵ KU Leuven, Department of Cardiovascular Sciences, Laboratory of Experimental Cardiology, Belgium and K.G. Jebsen Center for Cardiac Research, University of Oslo, 3000 Leuven, Oslo, Norway.
⁶ Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. Electronic address: apd10@medschl.cam.ac.uk.

Abstract

Unlabelled Image

Keywords: Angiotensin; Apelin; Bradykinin; COVID-19; Human cardiomyocytes; RNA-sequencing; SARS-CoV-2.