Chiral Transient Directing Group Strategies in Asymmetric Synthesis

Abstract

The development of novel methodologies for catalytic enantioselective functionalization reactions enabled by chiral transient directing groups is accompanying in a paradigm shift in the field of asymmetric synthesis. In particular, these highly atom- and step-economic enantioinduction processes commonly proceed either via enantioselective C-H functionalization, or via enantioselective hydroarylation of the pro-chiral substrates generating point, axial or planar chirality. The use of the transient directing group strategy in C-H functionalizations precludes the stoichiometric installations and removal of directing groups and enables efficient, more compatible and economical chemical routes. This minireview highlights asymmetric transition-metal-catalyzed methodologies involving chiral transient directing groups together with the scope, utility and future perspective of the field.

Keywords: Catalysis; C−H Functionalization; Enantioselective; Transient Directing Group; Transition-Metal.