Sensitivity and specificity of high-resolution wide field fundus imaging for detecting neovascular age-related macular degeneration

PLoS One. 2020 Aug 21;15(8):e0238072. doi: 10.1371/journal.pone.0238072. eCollection 2020.


Purpose: Early detection and treatment are important management strategies for neovascular age-related macular degeneration (AMD). The purpose of this study was to determine the sensitivity and specificity in detecting neovascular AMD using two wide-field imaging systems: ClarusTM (CLARUS 500™, Carl Zeiss Meditec AG, Jena, Germany) and Optos®(Optos California®, Optos PLC, Dunfermline, United Kingdom), compared to conventional digital fundus photographs.

Methods: We retrospectively analyzed 109 eyes of 73 consecutive patients with neovascular AMD, who underwent standard examination and multimodal imaging, including fundus photography, and optical coherence tomography (OCT). Unmasked graders utilized slit-lamp biomicroscopy and OCT to diagnose neovascular AMD. Masked graders evaluated ClarusTM, Optos®, and digital fundus photograph methods to determine the presence of choroidal neovascularization associated with AMD. Sensitivity and specificity analyses were performed using combined fundoscopy and OCT as the reference standard.

Results: Ninety eyes were diagnosed with neovascular AMD and the remaining 19 eyes were normal based on the reference standard. Of these, neovascular AMD was detected using ClarusTM in 94.4% (85/90). The sensitivities of Optos® and digital fundus photographs were 81.1% (73/90) and 87.8% (79/90), respectively. The specificities using ClarusTM, Optos®, and digital fundus photographs were 89.5% (17/19), 94.7% (18/19), and 89.5% (17/19), respectively.

Conclusion: ClarusTM, with its ability to image high-resolution wide field fundus, was considered superior for diagnosing neovascular AMD with high sensitivity and specificity. It may be a useful screening tool for early detection of neovascular AMD, facilitating prompt referral and treatment.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Fundus Oculi
  • Humans
  • Macular Degeneration / diagnosis*
  • Macular Degeneration / pathology
  • Male
  • Middle Aged
  • Photography / methods
  • Retrospective Studies
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Tomography, Optical Coherence / methods

Grants and funding

The authors received no specific funding for this work.