Post-fever retinitis - Newer concepts

Indian J Ophthalmol. 2020 Sep;68(9):1775-1786. doi: 10.4103/ijo.IJO_1352_20.


Post-fever retinitis (PFR) is an infectious or para-infectious uveitic entity caused by bacterial or viral agents and seen mainly in tropical countries. Systemic symptoms such as joint pain, skin rash are common during the febrile stage. On the basis of only clinical presentation, it is difficult to pin-point the exact etiology for PFR. Serological investigations, polymerase chain reaction, and knowledge of concurrent epidemics in the community may help to identify the etiological organism. Bacterial causes of PFR such as rickettsia and typhoid are treated with systemic antibiotics, with or without systemic steroid therapy, whereas PFR of viral causes such as chikungunya, dengue, West Nile virus, and Zika virus have no specific treatment and are managed with steroids. Nevertheless, many authors have advocated mere observation and the uveitis resolved with its natural course of the disease. In this article, we have discussed the clinical features, pathogenesis, investigations, and management of PFR.

Keywords: Chikungunya; Rickettsia; West Nile virus; Zika virus; dengue; post-fever retinitis; systemic steroids; typhoid.

Publication types

  • Review

MeSH terms

  • Chikungunya Fever*
  • Dengue*
  • Humans
  • Retinitis* / diagnosis
  • Retinitis* / etiology
  • Zika Virus Infection*
  • Zika Virus*